When it comes to unpacking, since I pack for myself and my son I unpack ASAP because I actually need a number of the items in the bag and sometimes like if the hotel had a pool there is wet stuff so that needs to go in the washing machine ASAP. Also otherwise in our small space the suitcase blocks access. And I make sure there is no food left over that might have been opened, the liquids have to be put away to prevent a disaster lol. We can't leave anything in the car really for safety reasons and often we don't use the car at all for a trip. There also are some really small items -like my son's braces wax or meds that need to be put away in their proper place. Before we leave I try to have all the laundry in the plastic laundry bag easily accessible so I can unzip the suitcase in our entrance way and dump it right in the machine.