What Are Saccharides and Why Are They Important?

Sugars That Heal: The New Healing Science of Glyconutrients
by Emil I. Mondoa, M.D.

"Sugars that heal" it sounds like a contradiction in terms, but it's the key to one of the most important breakthroughs in recent medical science. We've all been bombarded with warnings about the evils of consuming too much sugar. But, in fact, for our bodies to function properly, we need small amounts of eight essential sugars, only two of which - glucose and galactose - are commonly found in our limited, overprocessed diets. When all eight sugars are available, the health benefits can be breathtaking: Individuals regain their ability to fight disease, reactivate their immune systems, and are able to ward off infection. Based on cutting-edge research in the rapidly evolving science of glyconutrients, Sugars That Heal is an exciting new approach to health and disease prevention.

As medical doctor and scientific researcher Emil Mondoa explains, these eight essential sugars, known as saccharides, are the basis of multicellular intelligence - the ability of cells to communicate, cohere, and work together to keep us healthy and balanced. Even tiny amounts of these sugars - or lack of them - have profound effects. In test after test conducted at leading institutes around the world, saccharides have been shown to lower cholesterol, increase lean muscle mass, decrease body fat, accelerate wound healing, ease allergy symptoms, and allay autoimmune diseases such as arthritis, psoriasis, and diabetes. Bacterial infections, including the recurrent ear infections that plague toddlers, often respond remarkably to saccharides, as do many viruses - from the common cold to the flu, from herpes to HIV. The debilitating symptoms of chronic fatigue syndrome, fibromyalgia, and Gulf War syndrome frequently abate after adding saccharides. And, for cancer patients, saccharides mitigate the toxic effects of radiation and chemotherapy - while augmenting their cancer-killing effects, resulting in prolonged survival and improved quality of life.

Sugars That Heal offers a revolutionary new health plan based on the science of glyconutrients - foods that contain saccharides. It gives authoritative guidance for getting all eight saccharides conveniently into your diet through supplements and readily available foods, as well as detailed information on correct dosages. Here, too, are chapters dealing with the special nutritional needs of people suffering from cancer, heart disease, asthma, and neurological disorders, and methods for using glyconutrients to treat depression, obesity, and ADHD.

The more doctors learn about glyconutrients, the more excited they become about their long-term fundamental health benefits. Now, with this new book, the breakthroughs in the study of glyconutrients are available to everyone. Whether your goal is to prevent disease, live longer and better, or treat a serious illness that has eluded conventional medicine, Sugars That Heal is your essential guide to complete health.

Chapter 1

"It is not ... that some people do not know what to do with truth when it is offered them, but the tragic fate is to reach, after patient search, a condition of mind-blindness, in which the truth is not recognized, though it stares you in the face."

-Sir William Osler, physician, 1849-1919

Coley's Saccharides

Though he didn't know why they worked, more than a hundred years ago a Harvard-educated physician named William Coley figured out that saccharides could cure certain cancers.

In the fall of 1890, Elizabeth Dashiell, a delicate young woman of seventeen, was diagnosed with bone cancer in her right hand. Since her diagnosis had come early in the course of the disease, amputation of her afflicted arm below the elbow was swift. Yet she died a few months later. Her doctor, twenty-eight-year-old Harvard Medical School graduate William Coley, was distraught. A surgeon at New York's Memorial Hospital, which would later be renamed Memorial Sloan-Kettering Cancer Center, Coley began poring over old patient records - for what, he wasn't sure. As Coley read the dusty charts, he saw that most cancer therapies failed; most of the patients died. But curiously, one patient who was severely afflicted with sarcoma, a cancer of the connective tissue, did recuperate. Hospitalized and near death in the fall of 1884, he experienced two outbreaks of a severe skin infection called erysipelas. Caused by a strep bacterium, the infections resulted in high fevers and roused his immune system. The bumpy, plum-sized tumor below his left ear began to shrink and the patient rallied, recovering completely. When the tenacious Coley tracked the man down, he was well, with no cancer recurrence some seven years later.

Because Coley's discovery transpired more than a century ago when the immune system was uncharted territory, the scientist didn't understand how the patient's strep infection could bring about a cancer remission. Nevertheless, the prescient physician thought perhaps he had stumbled across something important - a novel way to treat cancer - and began a series of experiments on sarcoma patients. Coley's quest to reproduce what nature had so elegantly accomplished is detailed with heart-thumping vigor by writer Stephen Hall in his excellent book A Commotion in the Blood. According to Hall, after repeated failures in inoculating a sarcoma patient with live cultures of the strep bacterium, Coley eventually procured an exceptionally potent strain that induced a high fever and skin infection in the lucky man who received it. Within a few weeks the patient's neck tumors began to recede, eventually vanished, and didn't return for several years - and the young surgeon soon published his first paper.

Using live, virulent bacteria was, naturally, dangerous (in fact, two of Coley's patients died from resulting step infections), so the doctor eventually developed a safer method, devising a vaccine. After culturing the bacteria, Coley killed the colonies or filtered them out, his theory being that the toxins the cultured bacteria had produced were at least partly responsible for the tumor shrinkage. In due course, Coley added the toxins from a second bacterium, which today is called Serratia marcescens. That combination proved remarkably successful. On advanced, inoperable sarcomas he accomplished a cure rate of close to 20 percent with his treatment. When the toxin therapy was continued for six months after surgery, Coley's five-year remission rates soared to 80 percent, according to a retrospective study done by Coley's daughter. That figure rivals, and in some cases surpasses, current sarcoma treatment outcomes, without the long-term consequences of today's chemotherapies and radiation.

For a short time, Coley's toxins - also known as fever therapy because the treatment induced high fevers - was the only recognized systemic treatment for cancer other than surgery. Coley's crude bacterial immunotherapy, however, was never really accepted in scientific circles. Quality control was one reason. The toxins weren't standardized, nor was the dosing, and many physicians with inferior batches didn't get good results. In addition, vaccine therapy wasn't a top priority for pharmaceutical companies. There wasn't then, and there isn't now, much money in it. And since turn-of-the century medicine had no understanding of the immune system, scientists lacked the framework for understanding why the toxins worked. The final demise of toxin therapy came with the advent of radiation therapy.

At first, physicians often used the two therapies together. But as writer Stephen Hall explains, radiation became so fashionable that Coley's overzealous boss, the then-head of Memorial Hospital, Dr. James Ewing, advised his staff to use high-dose radiation not only for bone cancer but also for all instances of "persistent unexplained" bone pain. Meanwhile, Coley's toxins became yesterday's news, even though the treatment appeared to work better than radiation. Of twenty-four patients with inoperable sarcoma at Memorial Hospital treated with radiation alone, twenty-one were dead and the other three had had treatment too recent to evaluate.11 In contrast, of twenty-two inoperable sarcoma cases treated with Coley's toxins, some in conjunction with radiation, some not, twelve patients remained cancer-free after five years, the benchmark for a clinical cure.

Damn the statistics - radium was, in a word, hot, and Coley's toxins were not. Like lambs to the slaughter, the unsuspecting public joined the radium craze on an unregulated, recreational level. Dubbed "mild radium therapy" to distinguish it from the high radium levels reserved for cancer treatment, over-the-counter radium-enhanced products became de rigueur. Radium foot salves were up-to-the-minute at the turn of the century; for men only, a radium-fortified jockstrap was available. Manufacturers laced candy with radium and spiked designer water called Radithor with it, touting the one-dollar-a-bottle brew as an energy elixir for 150 "endocrinologic" ailments, from rheumatism and hypertension to exhaustion and sexual dysfunction. Indeed, the doctor's pamphlet that accompanied Radithor boasted that its "tonic effects upon the nervous system generally result in a great improvement in the sex organs." Not surprisingly, more than 400,000 bottles were sold.

Copyright © 2001 by Emil I. Mondoa, M.D.

About the Author

Emil I. Mondoa, M.D., is a practicing, board-certified pediatrician affiliated with Our Lady of Lourdes Medical Center in Camden, New Jersey; South Jersey Medical Center in Vineland, New Jersey; and the Alfred I. duPont Hospital for Children in Wilmington, Delaware. He also holds an MBA from the Wharton School, with a focus on health-care management. He is founder of the Glyconutrients Research Foundation.