(Page 2 of 3)

Dosing

Standardization

Standardization involves measuring the amount of certain chemicals in products to try to make different preparations similar to each other. It is not always known if the chemicals being measured are the "active" ingredients. Ginseng extracts may be standardized to 4% ginsenosides content (for example, G115®) or 7% total ginsenosides content. Standardized products have been used in studies, although tests of commercially available ginseng products have found that many brands do not contain the claimed ingredients, and some include detectable pesticides.

Adults (18 years and older)

Capsules: 100 to 200 milligrams of a standardized ginseng extract (4% ginsenosides) taken by mouth once or twice daily has been used in studies for up to 12 weeks. 0.5 to 2 grams of dry ginseng root, taken daily by mouth in divided doses, has also been used. E. senticosus dry extract at a dose of 300 milligrams per day was used in a small study for 8 weeks to improve quality of life in elderly patients. A proprietary ginseng root extract (Cold-FX, CV Technologies Inc., Edmonton, AB) has been studied in athletes for 28 days at a dose of 400 milligrams per day. Higher doses are sometimes given in studies or under the supervision of a qualified healthcare provider. Many different doses are used traditionally. Practitioners sometimes recommended that after using ginseng continuously for two to three weeks, people should take a break for one or two weeks, and that long-term dosing should not exceed 1 gram of dry root daily.

Decoction/Fluid Extract/Tincture: A decoction of 1 to 2 grams added to 150 milliliters of water, taken by mouth daily has been used; a 1:1 (grams per milliliter) fluid extract taken as 1 to 2 milliliters by mouth daily has been used; 5 to 10 milliliters (approximately 1 to 2 teaspoons) of a 1:5 (grams per milliliter) tincture taken by mouth daily has been used. Practitioners sometimes recommended that after using ginseng continuously for two to three weeks, people should take a break for one or two weeks.

Children (younger than 18 years)

There is not enough scientific information available to recommend the safe use of ginseng in children.

Preliminary study in infants with peri-anal abscess or fistula-in-ano, used a treatment of GTTC (Ginseng and Tang-kuei Ten Combination) at a dose of 0.1- 0.2 grams per kilogram of body weight twice a day to accelerate recovery. Further research is needed to confirm these study results.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Allergies

People with known allergy to plants in the Araliaceae family should avoid ginseng.

Side Effects and Warnings

Ginseng has been well tolerated by most people in scientific studies when used at recommended doses, and serious side effects appear to be rare.

Based on limited evidence, long-term use may be associated with skin rash or spots, itching, diarrhea, sore throat, loss of appetite, excitability, anxiety, depression, or insomnia. Less common reported side effects include headache, fever, dizziness/vertigo, blood pressure abnormalities (increases or decreases), chest pain, difficult menstruation, heart palpitations, rapid heart rate, leg swelling, nausea/vomiting, or manic episodes in people with bipolar disorder.

Based on human research, ginseng may lower blood sugar levels. This effect may be greater in patients with diabetes than in non-diabetic individuals. Caution is advised in patients with diabetes or hypoglycemia, and in those taking drugs, herbs, or supplements that affect blood sugar. Serum glucose levels may need to be monitored by a healthcare provider, and medication adjustments may be necessary.

There are anecdotal reports of nosebleeds and vaginal bleeding with ginseng use, although scientific study is limited in this area. There is also evidence in humans of ginseng reducing the effectiveness of the "blood thinning" medication warfarin (Coumadin®). Caution is advised in patients with bleeding disorders or taking drugs that may affect the risk of bleeding or blood clotting. Dosing adjustments may be necessary. Several cases of severe drops in white blood cell counts were reported in people using a combination product containing ginseng in the 1970s, and may have been due to contamination.

Ginseng may have estrogen-like effects, and has been associated with reports of breast tenderness, loss of menstrual periods, vaginal bleeding after menopause, breast enlargement (reported in men), difficulty developing or maintaining an erection, or increased "sexual responsiveness." Avoid use of ginseng in patients with hormone sensitive conditions, such as breast cancer, uterine cancer, or endometriosis.

Ginseng may produce manic symptoms, based on a case report: In a single case report involving a 56 year-old woman with previous affective disorder, a manic episode was reported during ginseng intake. Symptoms disappeared rapidly with low doses of neuroleptics and benzodiazepines.

A severe life-threatening rash known as Stevens-Johnson syndrome occurred in one patient and may have been due to contaminants in a ginseng product. A case report describes liver damage (cholestatic hepatitis) after taking a combination product containing ginseng. High doses of ginseng have been associated with rare cases of temporary inflammation of blood vessels in the brain (cerebral arteritis), abnormal dilation of the pupils of the eye, confusion, or depression.

There is preliminary evidence that ginseng, at doses of 200 milligrams of extract daily, may increase the QTc interval (thus increasing the risk of abnormal heart rhythms) and decrease diastolic blood pressure two hours after ingestion in healthy adults.

Pregnancy and Breastfeeding

Ginseng has been used traditionally in pregnant and breastfeeding women. Animal studies and preliminary human research suggest possible safety, although safety has not been clearly established in humans. Therefore, ginseng use cannot be recommended during pregnancy or breastfeeding. There is a report of neonatal death and the development of male characteristics in a developing baby girl after exposure of a pregnant mother to ginseng.

Many tinctures contain high levels of alcohol and should be avoided during pregnancy.

Tags: Herbal Medicine

About the Author

medlineplus.gov
MedlinePlus will direct you to information to help answer health questions. MedlinePlus brings together authoritative information from NLM, the National Institutes of Health (NIH), and other government agencies and health-related organizations. MedlinePlus also has extensive information about drugs, an illustrated medical encyclopedia, interactive patient tutorials, and latest health news.