Bromelain

by MedlinePlus

Classified as an herb, bromelain is a sulfur-containing proteolytic digestive enzyme that is extracted from the stem and the fruit of the pineapple plant ( Ananas comosus , family Bromeliaceae ).

When taken with meals bromelain is believed to assist in the digestion of proteins; and when taken on an empty stomach to acts medicinally as an anti-inflammatory agent.

The expert panel, the German Commission E approved bromelain for the treatment of swelling/inflammation of the nose and sinuses caused by injuries and surgery in 1993.

Synonyms

Ananas sativus, Ananase®, Bromelain-POS, bromeline (pleural), Bromelainum, Bromeliaceae (family), Bromelin, Bromelins, Debridase, Phlogenzym (rutoside, bromelain, and trypsin), ERC (enzyme-rutosid combination -rutosid, bromelain, trypsin), plant protease concentrate, pineapple extract, Traumanase®.

Evidence

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Uses based on scientific evidence

Inflammation

Several preliminary studies suggest that when taken by mouth, bromelain can reduce inflammation or pain caused by inflammation. Better quality studies are needed to confirm these results.

Sinusitis

It is proposed that bromelain may be a useful addition to other therapies used for sinusitis (such as antibiotics) due to its ability to reduce inflammation/swelling. Studies report mixed results, although overall bromelain appears to be beneficial for reducing swelling and improving breathing. Better studies are needed before a strong recommendation can be made.

Burn debridement

A bromelain-derived debriding agent, Debridase, has been studied on deep second degree and third degree burns with positive results. Further results are needed to confirm these results.

Cancer

There is not enough information to recommend for or against the use of bromelain in the treatment of cancer, either alone or in addition to other therapies.

Chronic obstructive pulmonary disease (COPD)

There is not enough information to recommend for or against the use of bromelain in COPD.

Digestive enzyme/pancreatic insufficiency

Bromelain is an enzyme with the ability to digest proteins. However, there is little reliable scientific research on whether bromelain is helpful as a digestive aid. Better study is needed before a firm conclusion can be made.

Nutrition supplementation

There is not enough information to recommend for or against the use of bromelain as a nutritional supplement.

Osteoarthritis of the knee (OA)

In one study of a combination product ERC (enzyme-rutosid combination -rutosid, bromelain, trypsin) results showed that ERC may be considered as an effective and safe alternative to prescription anti-inflammatory drugs (NSAIDs) such as diclofenac in the treatment of painful episodes of OA of the knee. Further well-designed clinical trials of bromelain alone are needed to confirm these results.

Rheumatoid arthritis (RA)

There is not enough information to recommend for or against the use of bromelain in rheumatoid arthritis (RA). Notably, most studies and case reports in this area have been published by the same authors.

Steatorrhea (fatty stools due to poor digestion)

There is not enough information to recommend for or against the use of bromelain in the treatment of steatorrhea.

Urinary tract infection (UTI)

There is not enough information to recommend for or against the use of bromelain in urinary tract infections.

Uses based on tradition or theory

The below uses are based on tradition or scientific theories. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Acquired immune deficiency syndrome (AIDS), acute lateral ankle sprain, allergic rhinitis (hay fever), amyloidosis, angina, appetite suppressant, anthelmintic effects. atherosclerosis ("hardening" of the arteries), autoimmune disorders, back pain, blood clot treatment, bronchitis, bruises, bursitis, cancer prevention, carpal tunnel syndrome, cellulitis/skin infections, colitis, common cold, cough, diarrhea, epididymitis, episiotomy pain (after childbirth), food allergies, food lodged in the esophagus, frostbite, gout, heart disease, hemorrhoids, immune system regulation, antibiotic absorption problems in the gut, infections, indigestion, injuries, joint disease, "leaky gut" syndrome, menstrual pain, pain (general), pancreatic problems with food digestion, Peyronie's disease (abnormal curvature, pain, and scar tissue in the penis), platelet inhibition (blood thinner), pneumonia, poor absorption of digested food, poor blood circulation in the legs, upper respiratory tract infection, sciatica, scleroderma, shingles pain/post-herpetic neuralgia, shortening of labor, smooth muscle relaxation, sports or other physical injuries, staphylococcal bacterial infections, stimulation of muscle contractions, stomach ulcer/stomach ulcer prevention, swelling (after surgery or injury), tendonitis, thick mucus, thrombophlebitis, treatment of scar tissue, ulcerative colitis, varicose veins, wound healing.

Dosing

The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

Standardization

Standardization involves measuring the amount of certain chemicals in products to try to make different preparations similar to each other. It is not always known if the chemicals being measured are the "active" ingredients. Bromelain may be standardized to milk clotting units (MCU), gelatin digesting units (GDU), FIP units, or Rorer units (RU) per gram. The milk clotting unit of measurement is officially recognized by the Food Chemistry Codex. Some experts recommend using bromelain standardized to contain at least 2000 MCU in each gram, although other sources recommend a range between 1200 to 1800 MCU per gram.

Adults (18 years and older)

Tablets (by mouth): A variety of doses have been used and studied. Research in the 1960s and 1970s used 120 to 240 milligrams of bromelain concentrate tablets daily (Traumanase® or Ananase®; 2500 Rorer units per milligram) in three to four divided doses for up to one week to treat inflammation. The German expert panel, the Commission E, has recommended 80 to 320 milligrams (200 to 800 FIP units) taken two to three times per day. Some authors recommend 500 to 1000 milligrams of bromelain to be taken three times daily, and many manufacturers sell products standardized to 2000 GDU in 500mg tablets. Effects of bromelain may occur at lower doses, and treatment may be started at a low dose and increased as needed.

Cream (applied to the skin): Cream containing a 35% bromelain in an oil-containing base has been used to clean wounds.

Children (younger than 18 years)

There is not enough scientific research to recommend safe use of bromelain in children.

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