The Nervous System : Cocaine, Chloral Hydrate, Chloroform

Hygienic Physiology: with Special Reference to the Use of Alcoholic Drinks and Narcotics
by Joel Dorman Steele, Ph.D.

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4. Chloral Hydrate

Chloral Hydrate is a drug frequently used to cause sleep. It leaves behind no headache or lassitude, as is often the case with morphine. It is, however, a treacherous remedy. It is cumulative in its effects, i. e., even a small and harmless dose, persisted in for a long period, may produce a gradual accumulation of evil results that in the end will prove fatal.

The Physiological Effect of its prolonged use is very marked. The appetite becomes capricious. The secretions are unnatural. Nausea and flatulency often ensue. Then the nervous system is involved. The heart is affected. Sleep, instead of responding to the drug, as at first, is broken and disturbed. The eyesight fails. The circulation is enfeebled, and the pulse becomes weak, rapid, and irregular. There is a tendency to fainting and to difficult respiration. Sometimes the impoverished blood induces a disease resembling scurvy, the ends of the fingers ulcerate, and the face is disfigured by blotches. An excessive dose may result in death.

Prolonged habitual use of chloral hydrate tends to debase the mind and morals of the subject in the same manner as indulgence in alcohol, ether, or chloroform.

5. Chloroform

Chloroform is an artificial product generally obtained, by distillation, from a mixture of chloride of lime, water, and alcohol. It was discovered in 1831 by Samuel Guthrie, of Sackett's Harbor, New York. It is a colorless, transparent volatile liquid, with a strong ethereal odor.

Physiological Effect. - Chloroform is a powerful anesthetic, which, when inhaled, causes a temporary paralysis of the nervous system, an. Therefore a complete insensibility to pain. There is great peril attending its use, even in the hands of the most skillful and experienced practitioners. It is sometimes prescribed by a physician, and afterward (as in the case of laudanum, morphine, and chloral) the sufferer, charmed with the release from pain and the peaceful slumber secured, buys the Lethean liquid for himself. Its use soon becomes an apparent necessity. The craving for the narcotic at a stated time is almost irresistible. The patient, compelled to give up the use of chloroform, will demand, entreat, pray for another dose, in a heartrending manner, never to be forgotten. Paleness and debility, the earliest symptoms, are followed by mental prostration. Familiarity with this dangerous drug begets carelessness, and its victims are frequently found dead in their beds, with the handkerchief from which they inhaled the volatile poison clutched in their lifeless hands.

6. Cocaine

Cocaine is an alkaloid prepared from the erythroxylon coca, a shrub, five or six feet high, found wild in the mountainous regions of Ecuador and Peru, where it is also cultivated by the natives. The South American Indians, for centuries, have chewed coca leaves as a stimulant, but the highly poisonous principle, now called cocaine, to which the plant owes its peculiar effects, was not discovered till 1859. Within a few years this drug has come into favor as an agent to produce local anesthesia, and has proved exceedingly valuable in surgical operations upon the eye and other sensitive organs. It has already, however, been diverted from its legitimate use as a benefaction, and to the other evils of the day is now added the "cocaine habit," which is, perhaps, even more dangerous and difficult to abandon than either the alcohol or the opium habit.

Physiological Effect. - Applied locally, cocaine greatly lessens and even annihilates pain. Taken internally, it acts as a powerful stimulant to the nervous system, its physiological action being similar to that of theine, caffeine, and theobromine. Used hypodermically, its immediate effect, says one to whom it was administered, is to cause "great pallor of countenance, profuse frontal perspiration, sunken eyes, enlarged pupils, lessened sensitiveness of the cornea and conjunctiva, lowered arterial tension, and a feeble pulse and heart beat. Under its influence I could not reason. Everything seemed to run through my brain, and in vain I summoned all my will power to overcome an overwhelming sleepiness." A few doses of this drug will in some persons produce temporary insanity. Used to excess, it leads to permanent madness or idiocy. "Cocaine," says a writer in the Medical Review, "is a dangerous therapeutic toy not to be used as a sensational plaything. If it should come into as general use as the other intoxicants of its class, it will help to fill the asylums, inebriate and insane."