Is it really possible to change the structure and function of the brain, and in so doing alter how we think and feel? The answer is a resounding yes. In late 2004, leading Western scientists joined the Dalai Lama at his home in Dharamsala, India, to address this very question - and in the process brought about a revolution in our understanding of the human mind. In this fascinating and far-reaching book, Wall Street Journal science writer Sharon Begley reports on how cutting-edge science and the ancient wisdom of Buddhism have come together to show how we all have the power to literally change our brains by changing our minds. These findings hold exciting implications for personal transformation.

For decades, the conventional wisdom of neuroscience held that the hardware of the brain is fixed and immutable - that we are stuck with what we were born with. As Begley shows, however, recent pioneering experiments in neuroplasticity, a new science that investigates whether and how the brain can undergo wholesale change, reveal that the brain is capable not only of altering its structure but also of generating new neurons, even into old age. The brain can adapt, heal, renew itself after trauma, and compensate for disability.

Begley documents how this fundamental paradigm shift is transforming both our understanding of the human mind and our approach to deep-seated emotional, cognitive, and behavioral problems. These breakthroughs show that it is possible to reset our happiness meter, regain the use of limbs disabled by stroke, train the mind to break cycles of depression and OCD, and reverse age-related changes in the brain. They also suggest that it is possible to teach and learn compassion, a key step in the Dalai Lama's quest for a more peaceful world. But as we learn from studies performed on Buddhist monks, an important component in changing the brain is to tap the power of mind and, in particular, focused attention. This is the classic Buddhist practice of mindfulness, a technique that has become popular in the West and that is immediately available to everyone.

With her extraordinary gift for making science accessible, meaningful, and compelling, Sharon Begley illuminates a profound shift in our understanding of how the brain and the mind interact. This tremendously hopeful book takes us to the leading edge of a revolution in what it means to be human.

Chapter 1

Challenging the Dogma of the Hardwired Brain The northern Indian district of Dharamsala is composed of two towns, lower Dharamsala and upper. The mist-veiled peaks of the Dhauladhar ("white ridge") range hug the towns like the bolster on a giant's bed, while the Kangra Valley, described by a British colonial official as "a picture of rural loveliness and repose," stretches into the distance. Upper Dharamsala is also known as McLeod Ganj. Founded as a hill station in the nineteenth century during the days of British colonial rule, the bustling hamlet (named after Britain's lieutenant governor of Punjab at the time, David McLeod) is built on a ridge, where hiking the steep dirt path from one guesthouse to another requires the sure-footedness of a goat and astute enough planning that you don't make the ankle-turning trek after dark and risk tumbling into a ravine.

Cows amble through intersections where street peddlers squat behind cloths piled with vegetables and grains, and taxis play a game of chicken with oncoming traffic, seeing who will lose his manhood first by edging his car out of the single lane of the town's only real thoroughfare. The road curves past beggars and holy men who wear little but a loincloth and look as if they have not eaten since last week, yet whose many woes are neatly listed on a computer printout that they hopefully thrust at any passerby who slows even half a pace. Barefoot children dart out of nowhere at the sight of a Westerner and plead, "Please, madam, hungry baby, hungry baby," pointing vaguely toward the open-air stalls that line the road.

From the flagstoned terrace of Chonor House, one of the guesthouses, all of Dharamsala spreads out before you. As soon as the sun is up, the maroon-robed monks are scurrying to prayers and the holy men crouched in back alleys are chanting om mani padme hum ("hail to jewel in the lotus"). Prayer scarves fluttering from boughs carry the Tibetan words May all sentient beings be happy and free from suffering. The prayers are supposed to be carried by the wind, and when you see them, you think, Wherever the wind blows, may those they touch find freedom from their pain.

Although lower Dharamsala is inhabited mostly by Indians, residents of McLeod Ganj are almost all Tibetan (with a sprinkling of Western expatriates and spiritual tourists), refugees who followed Tenzin Gyatso, the fourteenth Dalai Lama, into exile. Many of those remaining in Tibet, unable to flee themselves, have their toddlers and even infants smuggled across the border to Dharamsala, where they are cared for and educated at the Tibetan Children's Village ten minutes above the town. For the parents, the price of ensuring that their children are educated in Tibetan culture and history, thus keeping their nation's traditions and identity from being erased by the Chinese occupation, is never seeing their sons and daughters again.

McLeod Ganj has been the Dalai Lama's home in exile and the headquarters of the Tibetan government in exile since 1959, when he escaped ahead of Chinese Communist troops, which had invaded Tibet eight years earlier. His compound, just off the main intersection where buses turn around and taxis wait for fares, is protected around the clock by Indian troops toting machine guns. The entrance is a tiny hut whose physical presence is as humble as the guards are thorough. From its anteroom, large enough for only a small sofa, dog-eared publications in a wooden rack, and a small coffee table, you pass through a door into the security room, where you place everything you want to bring in (bags, notebooks, cameras, tape recorders) on the X-ray belt before entering a closet-size booth, curtained at both ends, for the requisite pat-down by Tibetan guards.

Once cleared, you amble up an inclined asphalt path that winds past more Indian security guards draped with submachine guns and lounging in the shade. The sprawling grounds are forested with pines and rhododendrons; ceramic pots spilling purple bougainvillea and saffron marigolds surround the widely spaced buildings. The first structure to your right is a one-story building that houses the Dalai Lama's audience chamber, also guarded by an Indian soldier with an automatic weapon. Just beyond is the Tibetan library and archives, and farther up the hill, the Dalai Lama's two-story private compound, where he sleeps, meditates, and takes most of his meals. The large structure to the left is the old palace where the Dalai Lama lived before his current residence was built. Mostly used for ordinations, for the next five days its large main room will be the setting for an extraordinary meeting. Brought together by the Mind and Life Institute in October 2004, leading scholars from both the Buddhist and the Western scientific traditions will grapple with a question that has consumed philosophers and scientists for centuries: does the brain have the ability to change, and what is the power of the mind to change it?

Hardwired Dogma

Just a few years before, neuroscientists would not even have been part of this conversation, for textbooks, science courses, and cutting-edge research papers all hewed to the same line, as they had for almost as long as there had been a science of the brain.

No less a personage than William James, the father of experimental psychology in the United States, first introduced the word plasticity to the science of the brain, positing in 1890 that "organic matter, especially nervous tissue, seems endowed with a very extraordinary degree of plasticity." By that, he meant "a structure weak enough to yield to an influence." But James was "only" a psychologist, not a neurologist (there was no such thing as a neuroscientist a century ago), and his speculation went nowhere. Much more influential was the view expressed succinctly in 1913 by Santiago Ramón y Cajal, the great Spanish neuroanatomist who had won the Nobel Prize in Physiology or Medicine seven years earlier. Near the conclusion of his treatise on the nervous system, he declared, "In the adult centers the nerve paths are something fixed, ended and immutable." His gloomy assessment that the circuits of the living brain are unchanging, its structures and organization almost as static and stationary as a deathly white cadaver brain floating in a vat of formaldehyde, remained the prevailing dogma in neuroscience for almost a century. The textbook wis- dom held that the adult brain is hardwired, fixed in form and function, so that by the time we reach adulthood, we are pretty much stuck with what we have.

Copyright © 2007 by Sharon Begley.

About the Author

Sharon Begley, science columnist for The Wall Street Journal, inaugurated the paper's "Science Journal" in 2002. She was previously the senior science writer at Newsweek, covering neuroscience, genetics, physics, astronomy, and anthropology. The co-author of The Mind and the Brain, she has won many awards for her articles She is a frequent guest on radio and television, including The Charlie Rose Show, Today Weekend, CBS's The Early Show, and Imus in the Morning. She lives in New Jersey.