Vitamin E Supplements Safety

by Health Canada

While vitamin E from dietary sources is needed to maintain good health, people often take vitamin E supplements in the belief that they may prevent disease. Recent studies, however, have suggested that the use of high doses of vitamin E may actually increase the risk of heart disease and cancer in people who are at high risk for these diseases.

Vitamin E is the term used for a group of fat-soluble antioxidants, which act in the body to protect against cell damage. Vitamin E exists in eight different forms. Each form has its own biological activity, which is the measure of potency in the body. Alpha-tocopherol is the name of the most active form of vitamin E in humans. It is also a powerful biological antioxidant. Vitamin E is also thought to play a role in maintaining the body's immune system and other body processes.

Vitamin E supplements are usually sold in a form that protects the ability of the supplement to act as an antioxidant. The synthetic form of vitamin E is only half as active as the natural form. The synthetic form is labelled "dl" or "all rac," while the natural form is labelled "d" or "RRR."

The recommended dietary allowance (RDA) of vitamin E for people aged 14 years and over, including pregnant women, is 15 mg/d of alpha-tocopherol. This is equivalent to 22 IU (International Units) of natural source vitamin E per day, or 33 IU from synthetic sources. The RDA for breastfeeding women is 28 IU natural/42 IU synthetic vitamin E. The tolerable upper intake level for adults is 1,000 mg per day of any form of vitamin E supplements.

Vitamin E is found naturally in such foods as:

• vegetable oils such as sunflower, safflower, canola, and olive
• seeds and nuts such as sunflower seeds, almonds, hazelnuts, and peanuts
• wheat germ
• some green leafy vegetables, although it is present in small amounts.

Vitamin E is also added to some foods as an antioxidant, but only in small amounts.

Vitamin E deficiency is rare in humans. Since vitamin E is a fat-soluble vitamin, deficiency usually occurs only in people with syndromes where fat is poorly absorbed. However, because most dietary vitamin E is found in oils, very low-fat diets can result in low intakes of vitamin E if food choices are not made carefully. To maintain vitamin E levels, it is important to eat a variety of antioxidant-rich foods such as fruits, vegetables, whole grains, and moderate amounts of healthy unsaturated fats, (such as those found in fish, olive oil, canola oil, some vegetable oils, nuts, and flaxseed), as part of a healthy diet.

Vitamin E Supplements

In general, an intake of vitamin E (for example as part of multivitamin supplementation) of up to 40 IU is considered to be a "normal" dose. Supplements are available that provide from 1.5 IU to 1,500 IU per day. Those providing 400 IU per day or more are considered to be "high dose" or "megadose."

Currently, vitamin E is not authorized for sale in Canada for the purpose of preventing any particular disease, including heart disease and cancer. Health Canada is developing guidelines for vitamin E that will recommend precautionary measures for people aged 55 years or older who have heart disease or diabetes, and for people who have, or have previously had, cancer. These people are advised to consult their doctor before taking doses of vitamin E of 400 IU or more. Also, people who are taking blood thinners, or have been diagnosed with a bleeding disorder and/or a vitamin K deficiency should consult their doctor before taking vitamin E.

Potential Benefits of Vitamin E Supplements

Some types of cell damage and disease are thought to be caused by the "oxidant" action of free radicals, which are by-products normally generated by the body. Although it is recognized that vitamin E is an antioxidant and prevents free-radical reactions, the theory that vitamin E removes the free radicals and protects against a variety of diseases - such as heart disease, cancer, Alzheimer's disease, Parkinson's disease and age-related macular degeneration, to name a few - has yet to be demonstrated with any certainty.

While most studies have found that people who consume diets rich in vitamin E are at a lower risk of developing heart disease or cancer, studies that looked at supplementation with high doses of vitamin E gave conflicting results.

A recent study involving healthy women found that 600 IU of natural vitamin E taken every second day did not prevent heart disease or cancer. The currently available scientific studies seem to indicate that there is no compelling evidence of benefits from high doses of vitamin E supplements against these diseases. However, more research is needed in this area.

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Health Canada is the Federal department responsible for helping Canadians maintain and improve their health, while respecting individual choices and circumstances.